For medicine

BIOSPORIN

Biosporin - a highly effective preparation on the basis of aerobic spore-forming bacteria for prophylactics and treatment of dysbacterioses, acute gastro-intestinal infections, purulent infections, a chronic stomatitis. Preparation Biosporin – combination of microorganisms which are characterized by high antagonistic activity to pathogenic and conditional pathogenic microorganisms and do not inhibit the normal microflora. The first domestic probiotic for human treatment.

Patented in Ukraine and Russia.

SUBALIN

Subalin - a highly effective biopreparation, based on the recombinant strain of aerobic spore-forming bacteria capable to produce human interferons. The preparation is effective towards to virus infectious agents, such as a flu, a herpes, a hepatitis, a meningoencephalitis and also has high antagonistic activity to a wide spectrum of pathogenic and conditional - pathogenic microorganisms. Combination of antibacterial and antivirus properties in one preparation - essentially new approach to treatment of many diseases mixed etiology.

Patented in Ukraine and Russia.

BATUMIN

Batumin is highly active antibiotic for treatment of staphylococcal infections on the basis of new compound – batumin, isolated from the bacterium of Pseudomonas genus. Antibiotic batumin has original chemical structure, and unique spectrum of antimicrobial action. The medication form – batumin ointment was developed for local treatment of staphylococcal infections.

Patented in Ukraine.

BETA-CAROTENE

Beta-Carotene – the highly active natural antioxidant, biological stimulator and precursor of vitamin A. It is used to decrease the damages caused by reactive oxygen, phototoxic molecules and chemical radicals at radioactive influence and also to prevent and treat oncological and heart-vessel diseases. Betacarotene stimulates cell regeneration processes and protects cell membranes (especially of liver cells), reduces skin and mucous membranes inflammation, increases the resistance of organism against infectious diseases, completely substitutes vitamin A and improves acuity of vision.

Patented in Ukraine.

GALACTOSOXIDASE

Galactosoxidase – an enzyme for analytical detection of galactose and its derivatives in various biological materials. A producer of galactosoxidase has been isolated at the Institute, the enzyme production method has been developed. The basic advantages of the domestic preparation compared to foreign analogs are as follows: high specificity and lack of impurities of other enzymatic activity. The preparation is used in medical practice for the diagnosis of hereditary children disease of galactosemia, as well as in the research work.

ELASTOTERASA IMMOBILISED

Elastoterasa immobilised – alraline serine protease, which is a component of proteolytic complex producing by Bacillus subtilis. The enzyme may be used in medicine for healing of wounds at burns of III-IY degree, trophic ulcers, purulent wounds at first stage of process.

Patented in Ukraine.

DIASTAPH

Diastaph High selectivity of batumin towards Staphylococcus species has been used to develop a novel diagnostic preparation DIASTAPH (batumin impregnated disks containing 5 μg of antibiotic) ensured quick and reliable identification of microorganisms of Staphylococcus genus in pure and (in the urgent cases) in mixed cultures.

MYCOMELANIN

Mycomelanin – new high-efficient preparation, isolated from biomass of melanin- containing fungi. The preparation has radioprotective, antioxidant, detoxicant and antitumour properties. It can be used in medicine and food industry, and also in the production of high-purity substances.

Patented in Ukraine.

HUMAN IMMUNOGLOBULINE FOR HERPES SIMPLEX VIRUS OF TYPE 2 TREATMENT (Immunoglobulinum humanum contra herpes simplex virus typus 2)

preparation for treatment of different diseases, caused by herpes simplex virus of type 2 , namely primary and recuring urogenital infection of men and women, genital herpetic infection of pregnant women and obstetric pathology related with this.

ANTICYTOMEGALOVIRUS HUMAN IMMUNOGLOBULINE (Immunoglobulinum anticytomegalovirus humanum fluid)

preparation is applied for treatment of the clinical display of cytomegalovirus infections of adults and children, in particular: cytomegalovirus pregnant infections with the complicated obstetric anamnesis for prevention of failure of pregnancy (prevention of threat of unmaturing, development of fetoplacental insufficiency, prenatal foetus death); CMV-infections of unpregnant women with the complicated obstetric anamnesis for prevention of failure of planned pregnancy; primary CMV-infections of expectant mothers with non burden anamnesis for prevention of obstetric complications; CMV-infections in new-born and children of junior age, which were born by infected mothers and have clinical displays of disease; CMVinfections of adults are with the defeat of central nerve system.

  

CITOBIOTEKT (Immunoglobulinum anticytomegalovirus humanum fluid for intravenous introduction)(Cytobiotect)

applied for treatment of cytomegalovirus infection at patients with an immunosuppression after transplantations. Patients have therapy of sharp CMV-infection with an immunodeficit, for example new-born, and also for patients with a medical immunosuppression or immunodeficit, caused other reasons (including by AIDS).

ZOSTEVIR (Immunoglobulinum humanum contra Varicella Zoster virus)

preparation is applied for treatment of patients with a herpetic infection with the defeat of the nervous system which is caused by Varicella Zoster virus.

GERPIMUN 6 (Immunoglobulinum humanum contra herpes virus typus 6 fluid)

preparation is applied for treatment of patients with a herpetic infection with the lesion of the nervous system caused by herpesvirus of type 6.

HUMAN IMMUNOGLOBULINE AGAINST EPSTEIN-BARR VIRUS (Immunoglobulinum humanum contra Epstein-Barr virus)

preparation is applied for treatment of mononucleosis infectious and diseases of central and peripheral nervous system, caused by Epstein-Barr virus, including encephalitis, encephalomyelitis, meningo-encephalitis, arachnoencephalitis, arachnoidits and others.

HUMAN IMMUNOGLOBULINE FOR CHLAMYDIA TRAHOMATIS TREATMENT (Immunoglobulinum humanum antichlamidicum)

preparation is applied for diseases caused by Chlamydia trahomatis, namely, urogenital lesions including the salpingitis, urethritis, prostatism, cystitis, unmaturing of pregnancy, etc.

HUMAN IMMUNOGLOBULINE AGAINST TOXOPLASMA GONDII (Immunoglobulinum humanum соntra Toxoplasma gondii)

preparation is applied for treatment of pregnant with toxoplasmosis and the obstetric pathology related with it, and also patients with the urogenital display on the toxopasmosis base.

LECTIVIR

Lectivir – preparation on basis of bacterial lectins for prophylaxis and treatment of influenza, herpes, hepatitis C and HIV/AIDS. Lectins possess unique specificity to different types of sialic acids and natural sialic acid-containing conjugates, can be used as analytical reagents to investigation and purification of glycoproteins, as molecular probes under analysis of surface cell structures.

Patented in Ukraine.

POLYMYXIN B

Polymyxin B – antibiotic of cyclopeptide origin for treatment infections caused by pathogenic gram-negative microorganisms Pseudomonas aeruginosa, Klebsiella pneumoniae, Salmonella and other bacteria resistant to antibiotics. Polymyxin B is also used for treatment patients with toxic shock state caused by mentioned bacteria and for preparative isolation of their toxins by complex formation. Polymyxin B is less toxic in comparison to the other polymyxins and therefore it can be used by intramuscular injection. The highly active, amucous and phage-resistant strains of Bacillus polymyxa were obtained by means of genetic selection and can be used in industry for polymyxin B production. The fermentation medium was optimized for maximal production of antibiotic during 72 hours of fermentation. The ratio between components B1, B2 and B3 in purified preparation of polymyxin B and its activity met the standards.

For industry

XAMPAN

Xampan - is bacterial origin preparation, which is dedicates for application in food-processing industry (as a thickener and structure forming agent and biologically active substance) and agriculture (as carrier of pesticide and growth regulators).

Patented in Ukraine.

EPAA

EPAA - is copolymer, which created on exopolysaccharide basis. This adhesive, created on exopolysaccharide basis, dedicated for the agriculture (for example improvement of soil physical and biological properties, its may be use as carrier for pesticide, nodule forming bacteria, phages and – agent of sands fixing), for textile (flament’s grinding and dyeing cloth), woodworking and microbiological industry as for household requirements too. The technology of EPAA reception has been developed. Preparation is ecologically safe and doesn’t contain harmful impurity (components).

Patented in Ukraine.

For agriculture

GAUPSIN

Gaupsin - the microbial biopreparation created on the basis of two active Pseudomonas aureofaciens strains possesses complex antimicrobial, antifungal, entomopathogenic and growth stimulating effect and is used for agricultural plants protection from diseases and pests. Gaupsin effectively protects the orchard from the apple worm and fungal diseases. It is used for the pre-sowing treatment of seeds, spraying of seedlings, processing of vine planting and forestries against the pests. P. aureofaciens strains are resistant to the chemical plant protection agents, so gaupsin is compatible with majority of fungicides and may be used in the form of mixtures. The preparation has no negative effect against the useful biocoenosis organisms, is harmless to people and mammals and may be used in any stage of plants development.

Patented in Ukraine.

AZOGRANE

Azograne – new high-efficiency granulated preparation of nitrogen-fixing bacteria Azotobacter vinelandii IMV V-7076. The preparation is created on the basis of the interaction of these bacteria with dispersed clay minerals. This interaction protects the bacterial cells from negative influence of extreme environmental factors. The preparation is characterized a high amount of bacterial cells, a stability at storage, a comfort at the use. The preparation placing in a root area of plants improves them nitric nutrition, provides an accumulation in the rhizosphere vitamins and other bioactive substances, stimulates development and substantially increases the productivity of plants.

Patented in Ukraine.

SUBALIN

Subalin - a highly effective biopreparation, based on the strain of aerobic sporeforming bacteria capable to human interferons production. The preparation is effective in relation to virus infectious agents, such as flu, herpes, Venezuelan encephalomyelitis and also has high antagonistic activity to a wide spectrum of pathogenic and conditional - pathogenic microorganisms. Introduction Subalin in the animal induces at them formation endogenous interferon, which provides antivirus protection of an organism. Combination antibacterial and antivirus properties in one preparation - essentially new approach to treatment of many diseases mixed aetiology.

Patented in Ukraine and Russia, Tts.

LITOSIL

Litosil is biopreservative preparation with complex action. The preparation is intended for forage plant ensilage for maximal preservation of its nutritive value. Litosil consists of selected lactic acid bacteria cultures that regulate purposefully microbiological processes, inhibit putrefactive microorganisms’ growth, synthesize biologically active substances (vitamins, amino acids, etc.), actively adhere to animal enterocytes, normalize its microflora.

ENDOSPORINUM

Endosporinum is highly effective etiotropic preparation- probiotic in treatment and prophylaxis intestinal and purulent infections, of postpartum endometritis, retained of fetal membranes ( afterbirth) and other inflammatory diseases of genital ways of dairy cattle and other species of agricultural animals. Endosporinum suppresses growth of pathogenic and conditionally pathogenic microflora, positively influences the pathogenesis of infection, stimulates protective immune reactions, moderates the severe signs of disease, cut down postpartum recovery period. It does not influence the quality of meat and milk production. Endosporinum is harmless for warm-blooded in doses the 200 times higher than those for therapeutical use. The preparation is lyophilic biomass of specially prepared bacteria, spores, bioactive metabolites and dried remains of the growth medium.

Patented in Ukraine.

LACTIN

Lactin is effective ecologically pure probiotic for prophylaxis of gut infections, disbacteriosis, for purposeful formation and stabilization of chicken microflora, normalization of metabolism, stabilization of protective forces of bird organism. The probiotic contains lactic acid bacteria – representatives of normal microflora of chicken digestive tract. They provide high biological activity, produce lactic acid, vitamins of group B, essential amino acids. Lactin has been trialled at Kyivska, Kharkivska and Crimean regions of Ukraine.

Patented in Ukraine.

BOVILACT

Bovilact is a biological product for young cattle – is natural remedy for protection of the animal organism against acute gastrointestinal diseases. It contains concentrated alive cells of highly effective cultures of lactic acid bacteria – producers of biologically active L-lactic acid, vitamins of group B, and essential amino acids.

Patented in Ukraine.

LACTOSAN

Lactosan - is high effective natural remedy for protection of pigs from gastrointestinal diseases (colibacteriosis, salmonelosis, disbacteriosis, etc.). The probiotic represents the alive lactic acid bacteria included in normal microflora of pig digestive tract and possessing biological activity: produce L - lactic acid, vitamins of group B, essential amino acids. Its efficiency is connected with caused beneficial metabolic changes in a digestive tract of pigs, better assimilation of a fodder, increase resistance of the organism, antagonism against opportunistic microorganisms. Lactosan is favourable alternative to antibiotics. The preparation is safe for environment because pig factory waste doesn’t contain harmful products distorting the ecological balance.

Patented in Ukraine.

NITRAGIN

Nitragin, Rhizobin – preparations on the basis of highly efficient, harmless nodule bacteria, symbionts of leguminous cultures: soybean, pea, alfalfa, lupine, goat’s-rue, trefoil, fodder beans, etc. The bacteria fix actively the atmospheric nitrogen and synthesize biologically active compounds. The presowing treatment of seeds of leguminous cultures by nitragin or rhizobin ensures the improvement of nitrogen nutrition and plant development, the yield increasing by 15—20 % and protein content increasing up to1.5-4.0 %. The use of the preparations favors the improvement of the ecological state of soils owing to their enrichment with nitrogen of stubble remains and structure renewal.

Patented in Ukraine.

AVERCOM

Avercom is a complex polyfunctioning preparation with nematocidal and phytostimulating action. The preparation includes in its structure an antiparasitic antibiotic avermectine, phospholipids, sterols, unsaturated fatty acids (oleic, linoleic, linolenic, arachidonic), phytohormones (indoleacetic acid, gibberellins, cytokinins: isopentiladenine, zeatin, zeatinriboside), amino acids, B group vitamins (thiamine, biotin, pyridoxine). The soil streptomycete Streptomyces avermitilis is a producer of those complex biologically active substances. Avercom is an ecologically safe preparation. It doesn’t possess the negative influence on microorganisms of soil, warm-blooded animals. Its usage in plant growing promotes to improve the phytosanitary state from parasitic phytonematodes, to raises productivity, allows to obtain the ecologically safe production. These properties provide an interest for using of Avercom in biological agriculture. Averсom is recommended for use of grain and vegetable cultures in field and greenhouse conditions.

Patented in Ukraine.

BTF (bio-turf fertilizer)

BTF (bio-turf fertilizer) – a new ecologically pure preparation for technical, vegetable, berry, fruit, and flower cultures grown under the field and greenhouse conditions. The preparation was created on the basis of turf, enriched by nitrogen-fixing and phosphate-mobilizing microorganisms, safe for people and animals. The use of BTU favors the improvement of mineral nutrition of plants and their provision with biologically active substances. The use of BTU guarantees the improvement of seed growing, intensive growth and development of plants, increasing of their resistance to diseases and pest. The preparation being used on the vegetable, berry and fruit cultures increases the yield by 15-20 %, quality of products improves at the expense of increase of saccharides and C vitamin content. The fertilizer application to flower cultures increases the number of flowers and the blossoming time.

Patented in Ukraine.

ECOVITAL

Ecovital – a complex ecologically safe multifunctional bacterial preparation for inoculation of leguminous plant seeds: soybean, pea, alfalfa, lupine, goat’s-rue, trefoil, fodder beans, etc. The preparation Ecovital is a highly effective composition of agronomical important soil microorganisms – nitrogen-fixing symbiotrophic rhizobia and phosphorus mobilizing bacteria Bacillus megaterium. The preparation improves the nitrogen and phosphorus plant nutrition by owing to formation on plant roots the powerful nitrogen-fixing apparatus and transformation of soil insoluble phosphates to available compounds. In addition, the preparation includes the biologically active metabolites of bacteria: vitamins, phytohormones, amino acids, antibiotic substances, etc. This ensures intensification of plant growth, increases of yield quantity and quality, protects plants from pathogens. There is also enriching of soil by main biogenic elements (nitrogen and phosphorus movable forms) and stimulating the development of useful soil microflora, stabilizing of agro-ecosystems, as well as promoting the preservation of soil fertility.

Patented in Ukraine.

AZOTOBACTERIN

Azotobacterin – a preparation based on highly efficient soil microorganisms of Azotobacter genus, harmless for people and animals. It is intended for seeds treatment and seedlings of technical and vegetable cultures grown under the field and greenhouse conditions. Cultures of microorganisms used for fertilizers production fix actively the atmospheric nitrogen, produce growth-stimulating compounds, vitamins, hormones, amino acids and antibiotic substances against phytopathogenic bacteria and fungi. Azotobacterin application favors the improvement of nitrogen nutrition and development of plants, increases their resistance to diseases. The preparations use guarantees the yield increase by 15-20 % under simultaneous increase of its quality. Azotobacterin is produced in liquid and dry forms.

Patented in Ukraine.

ECOPHOSPHORIN

Ecophosphorin – a preparation on the basis of highly efficient plant growthpromoting rhizobacteria Rhizobium radiobacter and phosphorus mobilizing bacteria Bacillus megaterium for the treatment of wheat seeds. The preparation includes the biologically active metabolites of bacteria: vitamins, phytohormones, amino acids, antibiotic substances, etc. This ensures intensification of plant growth, increases of yield quantity and quality, protects plants from pathogens. There is also enriching of soil by phosphorus movable forms and stimulating the development of useful soil microflora, stabilizing of agroecosystems, as well as preservation of soil fertility.

SPOROFIT

Sporofit is new biological preparation for plant protection. The preparation possesses a fungicide and bactericidal action. Sporofit disinfects seed from phytopathogenic microflora, raises plant resistance to illnesses. The application of sporofit provided crop increase more than on 20 %. The preparation is not toxic for people, animals and plants.

KOMPLEGRANE

Komplegrane – new high-efficiency granulated preparation of complex action for plant treatment on the basis of nitrogen-fixing bacteria Azotobacter vinelandii IMV V-7076 and phosphate-mobilizing bacteria Bacillus subtilis IMV V-7023. The preparation is cylindrical grey granules with diameter 3 mm. It is created on the basis of the interaction of these bacteria with fine-dispersed clay minerals. This interaction protects the bacterial cells from negative influence of extreme environmental factors. The preparation is characterized a high amount of bacterial cells, a stability at storage, a comfortable using. The preparation placing in a root area of plants improves their nitric and phosphoric nutrition, provides an accumulation in the rhizosphere vitamins and other bioactive substancesl, stimulates plant development, protects them from phytopathogenic microorganisms.

Patented in Ukraine.

Nature protecting technologies

BIOTECHNOLOGY FOR DECREASING METHANE IN MINE COALS

Biotechnology For Decreasing Methane In Mine Coals. It is known that up to 80% methane enters from the exhaust spaces to mine coals areas. The offered biotechnology is based on methane oxidation by methanotrophic bacteria. On the first stage bacteria grow on the mine fermentation equipment. After it they are immobilized on the rock surface which fills the exhaust spaces of mines. This is achieved by drawing of methanotroph suspension in the nutrition media on the rock surface. There methanotrophic bacteria consume methane, decrease amount on 60%. Application of the biotechnology substantially increases miners’ work safety.

МBC

МBC - granulated microbial biocatalyst, intended for effective purification industrial wastewater from toxic synthetic compounds, metal ions (Cr(VI), Cd2+, Cu2+, Hg2+, Ni2+, Co2+, Pb2+, Zn2+, etc.), radionuclides (137Cs, 90Sr, 60Co, uranium, plutonium, americium isotopes). MBC can be applied for concentration from solutions of rare-earth and precious metals (Ag, Au). Distinctive feature of MBC biotechnology is automatic activation of those physiological groups of microorganisms which are necessary for a detoxication of pollution depending on wastewater components.

Patented in Ukraine